Article
Circulating ADAM17 Level Reflects Disease Activity in Proteinase-3 ANCA-Associated Vasculitis.
Journal of the American Society of Nephrology : JASN - 1 Nov 2015
Bertram Anna, Lovric Svjetlana, Engel Alissa, Beese Michaela, Wyss Kristin, Hertel Barbara, Park Joon-Keun, Becker Jan U, Kegel Johanna, Haller Hermann, Haubitz Marion, Kirsch Torsten
Abstract excerpt
ANCA-associated vasculitides are characterized by inflammatory destruction of small vessels accompanied by enhanced cleavage of membrane-bound proteins. One of the main proteases responsible for ectodomain shedding is disintegrin and metalloproteinase domain-containing protein 17 (ADAM17). Given its potential role in aggravating vascular dysfunction, we examined the role of ADAM17 in active proteinase-3...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.