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Article

NF90 coordinately represses the senescence-associated secretory phenotype.

Aging - 1 Oct 2012

Tominaga-Yamanaka Kumiko, Abdelmohsen Kotb, Martindale Jennifer L, Yang Xiaoling, Taub Dennis D, Gorospe Myriam

Abstract excerpt

A hallmark trait of cellular senescence is the acquisition of a senescence-associated secretory phenotype (SASP). SASP factors include cytokines and their receptors (IL-6, IL-8, osteoprotegerin, GM-CSF), chemokines and their ligands (MCP-1, HCC4), and oncogenes (Gro1 and Gro2), many of them encoded by mRNAs whose stability and translation are tightly regulated. Using two models of human fibroblast senescence...

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Identifiers

PMID: 23117626
DOI: 10.18632/aging.100497
PMCID: PMC3517940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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