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Article

Clopidogrel pharmacodynamics and pharmacokinetics in the fed and fasted state: a randomized crossover study of healthy men.

Journal of clinical pharmacology - 1 Oct 2012

Hurbin Fabrice, Boulenc Xavier, Daskalakis Nikki, Farenc Christine, Taylor Theresa, Bonneau Damien, Lacreta Frank, Cheng Sue, Sultan Eric

Abstract excerpt

Clopidogrel requires CYP450-mediated hepatic metabolism to form its active metabolite (clopi-H4). This randomized, placebo-controlled, crossover study was designed to characterize the effect of a high-fat or standard breakfast on adenosine diphosphate (ADP)-induced platelet aggregation and exposu...

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Source

Identifiers

PMID: 22128201
DOI: 10.1177/0091270011419852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22128201-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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