Article
Precursor of ether phospholipids is synthesized by a flavoenzyme through covalent catalysis.
Proceedings of the National Academy of Sciences of the United States of America - 13 Nov 2012
Nenci Simone, Piano Valentina, Rosati Sara, Aliverti Alessandro, Pandini Vittorio, Fraaije Marco W, Heck Albert J R, Edmondson Dale E, Mattevi Andrea
Abstract excerpt
The precursor of the essential ether phospholipids is synthesized by a peroxisomal enzyme that uses a flavin cofactor to catalyze a reaction that does not alter the redox state of the substrates. The enzyme crystal structure reveals a V-shaped active site with a narrow constriction in front of the prosthetic group. Mutations causing inborn ether phospholipid deficiency, a very severe genetic disease, target...
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