Article
Epidermal growth factor-induced modulation of cytokeratin expression levels influences the morphological phenotype of head and neck squamous cell carcinoma cells.
Cell and tissue research - 1 Jan 2013
Makarova Galina, Bette Michael, Schmidt Ansgar, Jacob Ralf, Cai Chengzhong, Rodepeter Fiona, Betz Thomas, Sitterberg Johannes, Bakowsky Udo, Moll Roland, Neff Andreas, Sesterhenn Andreas, Teymoortash Afshin, Ocker Matthias, Werner Jochen A, Mandic Robert
Abstract excerpt
The migratory ability of tumor cells requires cytoskeletal rearrangement processes. Epidermal growth factor receptor (EGFR)-signaling tightly correlates with tumor progression in head and neck squamous cell carcinomas (HNSCCs), and has previously been implicated in the regulation of cytokeratin (CK) expression. In this study, HNSCC cell lines were treated with EGF, and CK expression levels were monitored by...
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