Article
[Genomic approach to pathophysiology of rheumatoid arthritis].
Clinical calcium - 1 Nov 2012
Yamada Ryo
Abstract excerpt
Genetic studies identified multiple genes and polymorphisms that increase risk to develop rheumatoid arthritis. Genomic approach is characterized with its integrative style using mathematical and statistical models. Its main targets include (1)combinatorial effect of multiple genetic and environmental factors, (2)heterogeneity of pathological states and its individuality, and (3)their chronological heterogeneity....
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