Article
The high bone mass phenotype is characterised by a combined cortical and trabecular bone phenotype: findings from a pQCT case-control study.
Bone - 1 Jan 2013
Gregson Celia L, Sayers Adrian, Lazar Victor, Steel Sue, Dennison Elaine M, Cooper Cyrus, Smith George Davey, Rittweger Jörn, Tobias Jon H
Abstract excerpt
High bone mass (HBM), detected in 0.2% of DXA scans, is characterised by a mild skeletal dysplasia largely unexplained by known genetic mutations. We conducted the first systematic assessment of the skeletal phenotype in unexplained HBM using pQCT in our unique HBM population identified from screening routine UK NHS DXA scans. pQCT measurements from the mid and distal tibia and radius in 98 HBM cases were...
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