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Article

All-transretinoic acid in the treatment of pediatric acute promyelocytic leukemia

1 Sept 2012

Abstract excerpt

Acute promyelocytic leukemia (APL) is a rare form of acute myeloid leukemia with specific epidemiological, pathogenetic and clinical features. Its frequency varies widely among nations, with a decreased incidence among 'Nordic' origin populations. The molecular hallmark of the disease is the presence of a balanced reciprocal translocation resulting in the PML/RAR-α gene fusion, which represents the target of the...

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PMID: 23098119
DOI: 10.1586/era.12.101

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