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Article

Acute Promyelocytic Leukemia in Children: A Model of Precision Medicine and Chemotherapy-Free Therapy.

International journal of molecular sciences - 11 Jan 2021

Gurnari Carmelo, Voso Maria Teresa, Girardi Katia, Mastronuzzi Angela, Strocchio Luisa

Abstract excerpt

Acute promyelocytic leukemia (APL) represents a paradigm of precision medicine. Indeed, in the last decades, the introduction of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) completely revolutionized the therapeutic approach to this previously highly fatal disorder. This entirely chemotherapy-free treatment, which provided excellent survival rates, has been initially validated in adults and,...

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Identifiers

PMID: 33440683
DOI: 10.3390/ijms22020642
PMCID: PMC7826974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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