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Mitochondrial haplogroup D4 confers resistance and haplogroup B is a genetic risk factor for high-altitude pulmonary edema among Han Chinese.

Genetics and molecular research : GMR - 9 Oct 2012

Luo Y J, Gao W X, Li S Z, Huang X W, Chen Y, Liu F Y, Huang Q Y, Gao Y Q

Abstract excerpt

High-altitude pulmonary edema (HAPE) is a life-threatening condition caused by acute exposure to high altitude. Accumulating evidence suggests that genetic factors play an important role in the etiology of HAPE. However, conclusions from association studies have been hindered by limited sample size due to the rareness of this disease. It is known that mitochondria are critical for hypoxic adaptation, and...

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Identifiers

PMID: 23096691
DOI: 10.4238/2012.October.9.1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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