Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Caffeine improves the ability of serotonin-deficient (Pet-1-/-) mice to survive episodic asphyxia.

Pediatric research - 1 Jan 2013

Cummings Kevin J, Commons Kathryn G, Trachtenberg Felicia L, Li Aihua, Kinney Hannah C, Nattie Eugene E

Abstract excerpt

BACKGROUND: In neonatal rodents, serotonin (5-HT) neurons are critical for successful autoresuscitation. We hypothesized that caffeine, a respiratory stimulant, would hasten the onset of gasping and improve autoresuscitation in 5-HT-deficient, Pet-1(-/-) mice. METHODS: Using a head-out system and electrocardiogram, we measured respiratory and heart rate (HR) responses of Pet-1(-/-) rodents and their littermates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analysis of Variance
Share to Caffeine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Primers

Share to Electrocardiography

Share to Heart Rate

Share to Mice, Knockout

Share to Respiration

Share to Serotonin

Source

Open in PubMed Open full text

Identifiers

PMID: 23095976
DOI: 10.1038/pr.2012.142
PMCID: PMC4399823

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caffeine improves the ability of serotonin-deficient (Pet-1-/-) mice to survive episodic asphyxia.PMID 23095976Read ↗

Failed heart rate recovery at a critical age in 5-HT-deficient mice exposed to episodic anoxia: implications for SIDS.Semantic proximity Read ↗

Genesis of gasping is independent of levels of serotonin in the Pet-1 knockout mouse.Semantic proximity Read ↗

Bradycardia in serotonin-deficient Pet-1-/- mice: influence of respiratory dysfunction and hyperthermia over the first 2 postnatal weeks.Semantic proximity Read ↗

Brainstem serotonin deficiency in the neonatal period: autonomic dysregulation during mild cold stress.Semantic proximity Read ↗

Subtle alterations in breathing and heart rate control in the 5-HT1A receptor knockout mouse in early postnatal development.Semantic proximity Read ↗

Necdin shapes serotonergic development and SERT activity modulating breathing in a mouse model for Prader-Willi syndromeSemantic proximity Read ↗

The in vivo respiratory phenotype of the adenosine A1 receptor knockout mouse.Semantic proximity Read ↗

Hypoxic ventilatory response in Tac1-/- neonatal mice following exposure to opioids.Semantic proximity Read ↗

A new physiologically realistic and clinically relevant model of sleep apnoea for investigating it’s effect as a comorbidity on neurodegenerative diseaseSemantic proximity Read ↗

The Ventilatory Response to Hypoxia in Mammals: Mechanisms, Measurement, and AnalysisSemantic proximity Read ↗

Serotonin, Etonogestrel and breathing activity in murine Congenital Central Hypoventilation SyndromeSemantic proximity Read ↗

Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.