Article
Failed heart rate recovery at a critical age in 5-HT-deficient mice exposed to episodic anoxia: implications for SIDS.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Sept 2011
Cummings Kevin J, Commons Kathryn G, Hewitt Julie C, Daubenspeck John A, Li Aihua, Kinney Hannah C, Nattie Eugene E
Abstract excerpt
Mice deficient in the transcription factor Pet-1⁻/⁻ have a ∼70% deficiency of brainstem serotonin [5-hydroxytryptamine (5-HT)] neurons and exhibit spontaneous bradycardias in room air at postnatal day (P)5 and P12 and delayed gasping in response to a single episode of anoxia at P4.5 and P9.5 (Cummings KJ, Li A, Deneris ES, Nattie EE. Am J Physiol Regul Integr Comp Physiol 298: R1333-R1342, 2010; and Erickson JT,...
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