Article
The role of autophagy: what can be learned from the genetic forms of amyotrophic lateral sclerosis.
CNS & neurological disorders drug targets - 1 Jul 2010
Pasquali Livia, Ruffoli Riccardo, Fulceri Federica, Pietracupa Sara, Siciliano Gabriele, Paparelli Antonio, Fornai Francesco
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder caused by loss of motor neurons both in the brain and spinal cord, which dramatically reduces life expectancy. ALS occurs either in familial ALS or, more frequently, in sporadic ALS forms. Several mechanisms have been postulated to underlie motor neuron death. In the present paper, starting from some of the genes related to familial ALS, we...
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