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Article

SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits.

European journal of human genetics : EJHG - 1 Jun 2013

Meirelles Osorio D, Ding Jun, Tanaka Toshiko, Sanna Serena, Yang Hsih-Te, Dudekula Dawood B, Cucca Francesco, Ferrucci Luigi, Abecasis Goncalo, Schlessinger David

Abstract excerpt

Measurement error and biological variability generate distortions in quantitative phenotypic data. In longitudinal studies with repeated measurements, the multiple measurements provide a route to reduce noise and correspondingly increase the strength of signals in genome-wide association studies (GWAS).To optimize noise correction, we have developed Shrunken Average (SHAVE), an approach using a Bayesian Shrinkage...

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PMID: 23092954
DOI: 10.1038/ejhg.2012.215
PMCID: PMC3658185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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