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A closed-tube methylation-sensitive high resolution melting assay (MS-HRMA) for the semi-quantitative determination of CST6 promoter methylation in clinical samples

22 Oct 2012

Abstract excerpt

BACKGROUND: CST6 promoter is highly methylated in cancer, and its detection can provide important prognostic information in breast cancer patients. The aim of our study was to develop a Methylation-Sensitive High Resolution Melting Analysis (MS-HRMA) assay for the investigation of CST6 promoter methylation. METHODS: We designed primers that amplify both methylated and unmethylated CST6 sequences after sodium...

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PMID: 23088560
DOI: 10.1186/1471-2407-12-486

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