Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hereditary spastic paraplegia-causing mutations in atlastin-1 interfere with BMPRII trafficking.

Molecular and cellular neurosciences - 1 Jan 2013

Zhao Jiali, Hedera Peter

Abstract excerpt

Disruption of the bone morphogenic protein (BMP)-linked signaling pathway has been suggested as an important factor in the development of hereditary spastic paraplegia (HSP). HSP-causing proteins spastin, spartin and NIPA1 were reported to inhibit the BMP pathway. We have previously shown a strong interaction of NIPA1 and atlastin-1 proteins. Hence, we investigated the role of another HSP-associated protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Protein Receptors, Type II
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COS Cells

Share to GTP-Binding Proteins

Share to Immunoprecipitation

Share to Microscopy, Confocal

Share to Protein Transport

Share to Spastic Paraplegia, Hereditary

Source

Open in PubMed Open full text

Identifiers

PMID: 23079343
DOI: 10.1016/j.mcn.2012.10.005
PMCID: PMC3587122

Genes

NIPA1
BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Hereditary spastic paraplegia-causing mutations in atlastin-1 interfere with BMPRII trafficking.PMID 23079343Read ↗

The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signallingSemantic proximity Read ↗

The effect of HSP-causing mutations in SPG3A and NIPA1 on the assembly, trafficking, and interaction between atlastin-1 and NIPA1.Semantic proximity Read ↗

Interaction of two hereditary spastic paraplegia gene products, spastin and atlastin, suggests a common pathway for axonal maintenance.Semantic proximity Read ↗

Targeted high-throughput sequencing identifies mutations in atlastin-1 as a cause of hereditary sensory neuropathy type I.Semantic proximity Read ↗

Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling.Semantic proximity Read ↗

Hereditary spastic paraplegia-associated mutations in the NIPA1 gene and its Caenorhabditis elegans homolog trigger neural degeneration in vitro and in vivo through a gain-of-function mechanism.Semantic proximity Read ↗

Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids.Semantic proximity Read ↗

Drosophila Atlastin regulates the stability of muscle microtubules and is required for synapse development.Semantic proximity Read ↗

AIDA-1/ANKS1B Binds to the SynGAP Family RasGAPs with High Affinity and Specificity.Semantic proximity Read ↗

S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model.Semantic proximity Read ↗

Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.