Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids.

doi:10.1371/journal.pgen.1005221

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Article

Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids.

PLoS genetics - 1 May 2015

Liu Zhiyu, Shi Herong, Szymczak Lindsey C, Aydin Taner, Yun Sijung, Constas Katharine, Schaeffer Arielle, Ranjan Sinthu, Kubba Saad, Alam Emad, McMahon Devin E, He Jingpeng, Shwartz Neta, Tian Chenxi, Plavskin Yevgeniy, Lindy Amanda, Dad Nimra Amir, Sheth Sunny, Amin Nirav M, Zimmerman Stephanie, Liu Dennis, Schwarz Erich M, Smith Harold, Krause Michael W, Liu Jun

Abstract excerpt

Bone morphogenetic proteins (BMPs) belong to the transforming growth factor β (TGFβ) superfamily of secreted molecules. BMPs play essential roles in multiple developmental and homeostatic processes in metazoans. Malfunction of the BMP pathway can cause a variety of diseases in humans, including cancer, skeletal disorders and cardiovascular diseases. Identification of factors that ensure proper spatiotemporal...

Topics

Amino Acid Sequence
Animals
Bone Morphogenetic Proteins
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Gene Expression Regulation
Genes, Reporter
Genetic Markers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glycosphingolipids

Molecular Sequence Data

Mutation

Phenotype

Sensitivity and Specificity

Sequence Analysis, DNA

Signal Transduction

Tetraspanins

Transcription Factors

Transforming Growth Factor beta

Source

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Identifiers

PMID: 25978409
DOI: 10.1371/journal.pgen.1005221
PMCID: PMC4433240

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