Article
Lack of association between IL6 single nucleotide polymorphisms and cardiovascular disease in Spanish patients with rheumatoid arthritis.
Atherosclerosis - 1 Dec 2011
López-Mejías Raquel, García-Bermúdez Mercedes, González-Juanatey Carlos, Castañeda Santos, Pérez-Esteban Silvia, Miranda-Filloy José A, Gómez-Vaquero Carmen, Fernández-Gutiérrez Benjamín, Balsa Alejandro, Pascual-Salcedo Dora, Blanco Ricardo, González-Álvaro Isidoro, Llorca Javier, Martín Javier, González-Gay Miguel A
Abstract excerpt
INTRODUCTION: Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis. IL-6 is a key mediator of inflammation in RA. A recent study showed an association between IL6-174 G/C gene polymorphism and cardiovascular (CV) disease in UK individuals with RA. To confirm this association we assessed the influence of three IL6 gene polymorphisms in the risk of CV...
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