Lack of association between JAK3 gene polymorphisms and cardiovascular disease in Spanish patients with rheumatoid arthritis.

doi:10.1155/2015/318364

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Article

Lack of association between JAK3 gene polymorphisms and cardiovascular disease in Spanish patients with rheumatoid arthritis.

BioMed research international - 1 Jan 2015

García-Bermúdez Mercedes, López-Mejías Raquel, Genre Fernanda, Castañeda Santos, Corrales Alfonso, Llorca Javier, González-Juanatey Carlos, Ubilla Begoña, Miranda-Filloy José A, Pina Trinitario, Gómez-Vaquero Carmen, Rodríguez-Rodríguez Luis, Fernández-Gutiérrez Benjamín, Balsa Alejandro, Pascual-Salcedo Dora, López-Longo Francisco J, Carreira Patricia, Blanco Ricardo, Martín Javier, González-Gay Miguel A

Abstract excerpt

Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs and polymorphisms in JAK3 gene have been associated with CV events in incident dialysis patients. Therefore, the aim...

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PMID: 25815310
DOI: 10.1155/2015/318364
PMCID: PMC4359874

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JAK3

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