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Association between neurotrophin-3 polymorphisms and executive function in Japanese patients with amnestic mild cognitive impairment and mild Alzheimer disease.

Dementia and geriatric cognitive disorders - 1 Jan 2012

Kobayashi Nobuyuki, Nagata Tomoyuki, Shinagawa Shunichiro, Nakayama Ritsuko, Kondo Kazuhiro, Nakayama Kazuhiko, Yamada Hisashi

Abstract excerpt

BACKGROUND: We investigated whether neurotrophin (NT)-3 polymorphisms influenced the executive function of patients with 2 separate disease stages with similar dementia conditions: amnestic mild cognitive impairment (A-MCI) or mild Alzheimer disease (AD). METHODS: Among 215 outpatients with dementia and MCI, 155 with mild AD (n = 108) or A-MCI (n = 47) were recruited and divided into three genotypic groups based...

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PMID: 23075484
DOI: 10.1159/000343075

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