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Interleukin-6 polymorphism and prostate cancer risk in population of Eastern Croatia.

Collegium antropologicum - 1 Sept 2013

Mandić Sanja, Sudarević Bojan, Marczi Saska, Horvat Vesna, Cosić Ivan, Mihaljević Slobodan, Milicević Nevenka, Simunović Dalibor, Galić Josip

Abstract excerpt

Recent studies suggest that chronic inflammation is crucial in the development and progression of prostate cancer (CaP). Interleukin-6 (IL-6) is a proinflammatory cytokine that plays an important role in intraprostatic inflammation and thus carcinogenesis. The -174G > C polymorphism of IL-6 gene has been associated with high IL-6 producer phenotype and an increased risk for CaP. The aim of this study was to...

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PMID: 24308236

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