Article
Genetic variations in key microRNA processing genes and risk of head and neck cancer: a case-control study in Chinese population.
PloS one - 1 Jan 2012
Ma Hongxia, Yuan Hua, Yuan Zhiyao, Yu Chenjie, Wang Ruixia, Jiang Yue, Hu Zhibin, Shen Hongbing, Chen Ning
Abstract excerpt
MicroRNAs (miRNAs) have been reported to play a key role in oncogenesis. Genetic variations in miRNA processing genes and miRNA binding sites may affect the biogenesis of miRNA and the miRNA-mRNA interactions, hence promoting tumorigenesis. In the present study, we hypothesized that potentially functional polymorphisms in miRNA processing genes may contribute to head and neck cancer (HNC) susceptibility. To test...
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