Article
Catenin family genes are not commonly mutated in hereditary diffuse gastric cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2012
Schuetz Johanna M, Leach Stephen, Kaurah Pardeep, Jeyes Jennifer, Butterfield Yaron, Huntsman David, Brooks-Wilson Angela R
Abstract excerpt
BACKGROUND: Approximately one third of the hereditary diffuse gastric cancer (HDGC) families carry germline mutations in the E-cadherin gene (CDH1). Risk prediction in members of families with this rare but deadly cancer could be improved by the identification of additional HDGC genes in non-CDH1 families. METHODS: Affected individuals from 22 CDH1 mutation-negative families were screened for germline mutations...
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