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JAML immunotherapy targets recently activated tumor-infiltrating CD8+ T cells

25 Jan 2023

Abstract excerpt

Junctional adhesion molecule-like protein (JAML) serves as a co-stimulatory molecule in γδ T cells. While it has recently been described as a cancer immunotherapy target in mice, its potential to cause toxicity, specific mode of action with regard to its cellular targets, and whether it can be targeted in humans remain unknown. Here, we show that JAML is induced by T cell receptor engagement, reveal that this...

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PMID: 36701231
DOI: 10.1016/j.celrep.2023.112040

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