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Article

Temporal regulation of topoisomerase IV activity in E. coli.

Molecular cell - 1 Jan 2003

Espeli Olivier, Levine Cindy, Hassing Heide, Marians Kenneth J

Abstract excerpt

We isolated a mutant allele of dnaX, encoding the tau and gamma subunits of the DNA polymerase III holoenzyme, that causes extreme cell filamentation but does not affect either cell growth or DNA replication. This phenotype results from a defect in daughter chromosome decatenation during rapid growth. In these cells, ParC, one subunit of topoisomerase IV, no longer associated with the replication factory, as...

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Identifiers

PMID: 12535532
DOI: 10.1016/s1097-2765(03)00013-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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