The BRAF(V600E) mutation is an independent, poor prognostic factor for the outcome of patients with low-risk intrathyroid papillary thyroid carcinoma: single-institution results from a large cohort study.

doi:10.1210/jc.2012-1775

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Article

The BRAF(V600E) mutation is an independent, poor prognostic factor for the outcome of patients with low-risk intrathyroid papillary thyroid carcinoma: single-institution results from a large cohort study.

The Journal of clinical endocrinology and metabolism - 1 Dec 2012

Elisei Rossella, Viola David, Torregrossa Liborio, Giannini Riccardo, Romei Cristina, Ugolini Clara, Molinaro Eleonora, Agate Laura, Biagini Agnese, Lupi Cristiana, Valerio Laura, Materazzi Gabriele, Miccoli Paolo, Piaggi Paolo, Pinchera Aldo, Vitti Paolo, Basolo Fulvio

Abstract excerpt

BACKGROUND: The BRAF(V600E) mutation, the most frequent genetic alteration in papillary thyroid carcinoma (PTC), was demonstrated to be a poor prognostic factor. The aim of this study was to evaluate its prognostic significance in a large cohort of low-risk intrathyroid PTC. METHODS: Among the 431 consecutive PTC patients, we selected 319 patients with an intrathyroid tumor and no metastases (T1-T2, N0, M0). The...

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PMID: 23066120
DOI: 10.1210/jc.2012-1775

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BRAF

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