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Article

BRAF V600E in thyroid cancer: navigating prognostic uncertainty and therapeutic opportunity.

European thyroid journal - 1 Dec 2025

Riesco-Eizaguirre Garcilaso

Abstract excerpt

This review explores the role of BRAF V600E in thyroid cancer with emphasis on its debated prognostic value, notable molecular heterogeneity, and opportunities as a therapeutic target. BRAF V600E, the most common oncogenic driver in papillary thyroid carcinoma, activates the MAPK pathway and suppresses genes involved in iodine metabolism and differentiation. While linked to adverse features and outcomes such as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41368991
DOI: 10.1530/ETJ-25-0225
PMCID: PMC12741945

Genes

BRAF

Variants

Provenance

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