Article
Usefulness of immunohistochemical expression analysis of metabolic-related molecules in differentiating between intracranial neoplastic and non-neoplastic lesions.
Brain tumor pathology - 1 Jul 2013
Makino Keishi, Nakamura Hideo, Hide Taku-ichiro, Yano Shigetoshi, Kuroda Jun-ichiro, Takahashi Yoshinobu, Iyama Ken-ichi, Kuratsu Jun-ichi
Abstract excerpt
As the histologic features of reactive glial proliferation seen in many non-neoplastic lesions and of diffusely infiltrating gliomas overlap, tumor-specific diagnostic markers are needed. A mutation in isocitrate dehydrogenase 1 (IDH1), the enzyme involved in lipid metabolism and glucose sensing,...
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