Article
Vascular disease-causing mutation R258C in ACTA2 disrupts actin dynamics and interaction with myosin.
Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 2015
Lu Hailong, Fagnant Patricia M, Bookwalter Carol S, Joel Peteranne, Trybus Kathleen M
Abstract excerpt
Point mutations in vascular smooth muscle α-actin (SM α-actin), encoded by the gene ACTA2, are the most prevalent cause of familial thoracic aortic aneurysms and dissections (TAAD). Here, we provide the first molecular characterization, to our knowledge, of the effect of the R258C mutation in SM α-actin, expressed with the baculovirus system. Smooth muscles are unique in that force generation requires both...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.