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Article

Mutational and expressional analyses of NRF2 and KEAP1 in sarcomas.

Tumori - 1 Jan 2000

Je Eun Mi, An Chang Hyeok, Yoo Nam Jin, Lee Sug Hyung

Abstract excerpt

AIMS AND BACKGROUND: Nuclear factor erythroid 2-related factor 2 (NRF2) activates expression of cytoprotective proteins such as GCLC and enhances cancer cell survival, whereas KEAP1 inhibits NRF2 by mediating NRF2 degradation. Somatic mutation of NRF2 and KEAP1 genes and loss of KEAP1 expression are detected in many carcinomas and contribute to cancer development. The aim of this study was to see whether...

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Source

Identifiers

PMID: 23052169
DOI: 10.1177/030089161209800417

Genes

KEAP1
GCLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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