Article
Mass spectrometry detection of G3m and IGHG3 alleles and follow-up of differential mother and neonate IgG3.
PloS one - 1 Jan 2012
Dechavanne Célia, Guillonneau François, Chiappetta Giovanni, Sago Laïla, Lévy Prisca, Salnot Virginie, Guitard Evelyne, Ehrenmann François, Broussard Cédric, Chafey Philippe, Le Port Agnès, Vinh Joëlle, Mayeux Patrick, Dugoujon Jean-Michel, Lefranc Marie-Paule, Migot-Nabias Florence
Abstract excerpt
Mass spectrometry (MS) analysis for detection of immunoglobulins (IG) of the human IgG3 subclass is described that relies on polymorphic amino acids of the heavy gamma3 chains. IgG3 is the most polymorphic human IgG subclass with thirteen G3m allotypes located on the constant CH2 and CH3 domains of the gamma3 chain, the combination of which leads to six major G3m alleles. Amino acid changes resulting of extensive...
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