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Genome-Wide Screening of Genes Regulated by DNA Methylation in Colon Cancer Development

1 Oct 2012

Abstract excerpt

Tumorigenesis is accompanied by changes in the DNA methylation pattern. Our aim was to test a novel approach for identification of transcripts at whole transcript level which are regulated by DNA methylation. Our approach is based on comparison of data obtained from transcriptome profiling of primary human samples and in vitro cell culture models. Epithelial cells were collected by LCM from normal, adenoma, and...

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PMID: 23049694
DOI: 10.1371/journal.pone.0046215

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