Article
A prioritization analysis of disease association by data-mining of functional annotation of human genes.
Genomics - 1 Jan 2012
Taniya Takayuki, Tanaka Susumu, Yamaguchi-Kabata Yumi, Hanaoka Hideki, Yamasaki Chisato, Maekawa Harutoshi, Barrero Roberto A, Lenhard Boris, Datta Milton W, Shimoyama Mary, Bumgarner Roger, Chakraborty Ranajit, Hopkinson Ian, Jia Libin, Hide Winston, Auffray Charles, Minoshima Shinsei, Imanishi Tadashi, Gojobori Takashi
Abstract excerpt
Complex diseases result from contributions of multiple genes that act in concert through pathways. Here we present a method to prioritize novel candidates of disease-susceptibility genes depending on the biological similarities to the known disease-related genes. The extent of disease-susceptibility of a gene is prioritized by analyzing seven features of human genes captured in H-InvDB. Taking rheumatoid...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.