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Functional genetic variations in the IL-23 receptor gene are associated with risk of breast, lung and nasopharyngeal cancer in Chinese populations.

Carcinogenesis - 1 Dec 2012

Zheng Jian, Jiang Lan, Zhang Liyuan, Yang Lei, Deng Jieqiong, You Yonghe, Li Na, Wu Hongchun, Li Wei, Lu Jiachun, Zhou Yifeng

Abstract excerpt

Interleukin-23 receptor (IL-23R) is a key element in the T-helper 17 cell-mediated inflammatory process, which plays an important role in the pathogenesis of cancer. In this study, we examined whether genetic polymorphisms in IL-23R are associated with cancer risk in 4936 cancer patients and 5664 control subjects from eastern and southern Chinese populations. We found that the C allele of the rs10889677A>C...

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PMID: 23042301
DOI: 10.1093/carcin/bgs307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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