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Article

Potentially functional polymorphisms in IL-23 receptor and risk of esophageal cancer in a Chinese population.

International journal of cancer - 1 Mar 2012

Chu Hongjun, Cao Weike, Chen Wei, Pan Shandong, Xiao Yong, Liu Yao, Gu Haiyong, Guo Wei, Xu Lin, Hu Zhibin, Shen Hongbing

Abstract excerpt

Interleukin-23 (IL-23)/IL-23 receptor (IL-23R) is essential for Th17 cell-mediated immune response, involved in autoimmune diseases and cancer pathogenesis. Two potentially functional genetic single nucleotide polymorphisms (SNPs; IL-23R rs6682925 T>C and rs1884444 T>G) were found to contribute to cancer susceptibility. In our study, we conducted a case-control study including 1,645 patients with esophageal...

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Identifiers

PMID: 21484795
DOI: 10.1002/ijc.26130

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