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Article

Evidence for early cognitive impairment related to frontal cortex in the 5XFAD mouse model of Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2013

Girard Stéphane D, Baranger Kévin, Gauthier Cyrielle, Jacquet Marlyse, Bernard Anne, Escoffier Guy, Marchetti Evelyne, Khrestchatisky Michel, Rivera Santiago, Roman François S

Abstract excerpt

The frontal cortex is a brain structure that plays an important role in cognition and is known to be affected in Alzheimer's disease (AD) in humans. Over the past years, transgenic mouse models have been generated to recapitulate the main features of this disease, including cognitive impairments. This study investigates frontal cortex dependent learning abilities in one of the most early-onset transgenic murine...

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Identifiers

PMID: 23042214
DOI: 10.3233/JAD-2012-120982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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