On the origin of Alzheimer's disease. Trials and tribulations of the amyloid hypothesis.

Abstract excerpt

The amyloid cascade hypothesis, which implicates the amyloid Aβ peptide as the pathological initiator of both familial and sporadic, late onset Alzheimer's disease (AD), continues to guide the majority of research. We believe that current evidence does not support the amyloid cascade hypothesis for late onset AD. Instead, we propose that Aβ is a key regulator of brain homeostasis. During AD, while Aβ accumulation...

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• Alzheimer Disease
• Amyloid beta-Peptides
• Amyloid beta-Protein Precursor
• Brain
• Disease Progression