Article
Congenital hypothyroidism mutations affect common folding and trafficking in the α/β-hydrolase fold proteins.
The FEBS journal - 1 Dec 2012
De Jaco Antonella, Dubi Noga, Camp Shelley, Taylor Palmer
Abstract excerpt
The α/β-hydrolase fold superfamily of proteins is composed of structurally related members that, despite great diversity in their catalytic, recognition, adhesion and chaperone functions, share a common fold governed by homologous residues and conserved disulfide bridges. Non-synonymous single nucleotide polymorphisms within the α/β-hydrolase fold domain in various family members have been found for congenital...
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