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Article

Primary generalized glucocorticoid resistance and hypersensitivity: the end-organ involvement in the stress response.

Science signaling - 2 Oct 2012

Charmandari Evangelia

Abstract excerpt

Primary generalized glucocorticoid resistance (PGGR or Chrousos syndrome) and primary generalized glucocorticoid hypersensitivity (PGGH) are rare genetic disorders characterized by generalized, partial target-tissue insensitivity or hypersensitivity to glucocorticoids, respectively, while also causing compensatory alterations in the activity of the hypothalamic-pituitary-adrenal axis. The molecular basis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23033539
DOI: 10.1126/scisignal.2003337

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