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Article

Common and rare variants of the THBS1 gene associated with the risk for autism.

Psychiatric genetics - 1 Dec 2014

Lu Lina, Guo Hui, Peng Yu, Xun Guanglei, Liu Yanling, Xiong Zhimin, Tian Di, Liu Yalan, Li Wei, Xu Xiaojuan, Zhao Jingping, Hu Zhengmao, Xia Kun

Abstract excerpt

OBJECTIVES: Autism is a severe neurodevelopmental disorder. Many susceptible or causative genes have been identified, and most of them are related to synaptogenesis. The THBS1 gene encodes thrombospondin 1, which plays a critical role in synaptogenesis of the central nervous system in the developing brain. However, no study has been carried out revealing that THBS1 is an autism risk gene. METHODS: We analyzed the...

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Source

Identifiers

PMID: 25304225
DOI: 10.1097/YPG.0000000000000054

Genes

THBS1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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