Identifying autism loci and genes by tracing recent shared ancestry.

doi:10.1126/science.1157657

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Article

Identifying autism loci and genes by tracing recent shared ancestry.

Science (New York, N.Y.) - 11 Jul 2008

Morrow Eric M, Yoo Seung-Yun, Flavell Steven W, Kim Tae-Kyung, Lin Yingxi, Hill Robert Sean, Mukaddes Nahit M, Balkhy Soher, Gascon Generoso, Hashmi Asif, Al-Saad Samira, Ware Janice, Joseph Robert M, Greenblatt Rachel, Gleason Danielle, Ertelt Julia A, Apse Kira A, Bodell Adria, Partlow Jennifer N, Barry Brenda, Yao Hui, Markianos Kyriacos, Ferland Russell J, Greenberg Michael E, Walsh Christopher A

Abstract excerpt

To find inherited causes of autism-spectrum disorders, we studied families in which parents share ancestors, enhancing the role of inherited factors. We mapped several loci, some containing large, inherited, homozygous deletions that are likely mutations. The largest deletions implicated genes, including PCDH10 (protocadherin 10) and DIA1 (deleted in autism1, or c3orf58), whose level of expression changes in...

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PMID: 18621663
DOI: 10.1126/science.1157657
PMCID: PMC2586171

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PCDH10

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