Article
Activating mutations in β-catenin in colon cancer cells alter their interaction with macrophages; the role of snail.
PloS one - 1 Jan 2012
Kaler Pawan, Augenlicht Leonard, Klampfer Lidija
Abstract excerpt
BACKGROUND: Tumor cells become addicted to both activated oncogenes and to proliferative and pro-survival signals provided by the abnormal tumor microenvironment. Although numerous soluble factors have been identified that shape the crosstalk between tumor cells and stroma, it has not been established how oncogenic mutations in the tumor cells alter their interaction with normal cells in the tumor...
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