Article
Human aortic valve calcification is associated with an osteoblast phenotype.
Circulation - 6 May 2003
Rajamannan Nalini M, Subramaniam Malayannan, Rickard David, Stock Stuart R, Donovan Janis, Springett Margaret, Orszulak Thomas, Fullerton David A, Tajik A J, Bonow Robert O, Spelsberg Thomas
Abstract excerpt
BACKGROUND: Calcific aortic stenosis is the third most common cardiovascular disease in the United States. We hypothesized that the mechanism for aortic valve calcification is similar to skeletal bone formation and that this process is mediated by an osteoblast-like phenotype. METHODS AND RESULTS: To test this hypothesis, we examined calcified human aortic valves replaced at surgery (n=22) and normal human valves...
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