Article
Genetic variation in DNMT3B and increased global DNA methylation is associated with suicide attempts in psychiatric patients.
Genes, brain, and behavior - 1 Feb 2013
Murphy T M, Mullins N, Ryan M, Foster T, Kelly C, McClelland R, O'Grady J, Corcoran E, Brady J, Reilly M, Jeffers A, Brown K, Maher A, Bannan N, Casement A, Lynch D, Bolger S, Buckley A, Quinlivan L, Daly L, Kelleher C, Malone K M
Abstract excerpt
Recently, a significant epigenetic component in the pathology of suicide has been realized. Here we investigate candidate functional SNPs in epigenetic-regulatory genes, DNMT1 and DNMT3B, for association with suicide attempt (SA) among patients with co-existing psychiatric illness. In addition, g...
Topics
- Adult
- Case-Control Studies
- DNA (Cytosine-5-)-Methyltransferases
- DNA Methylation
- Female
- Genetic Variation
- Genome, Human
- Haplotypes
- Humans
- Male
- Mental Disorders