Article
CBL mutations do not frequently occur in paediatric acute myeloid leukaemia.
British journal of haematology - 1 Dec 2012
Coenen Eva A, Driessen Emma M C, Zwaan C Michel, Stary Jan, Baruchel Andre, de Haas Valerie, de Bont Eveline S J M, Reinhardt Dirk, Kaspers Gertjan J L, Arentsen-Peters Susan T C J M, Meyer Claus, Marschalek Rolf, Pieters Rob, Stam Ronald W, van den Heuvel-Eibrink Marry M
Abstract excerpt
RAS-pathway mutations, causing a proliferative advantage, occur in acute myeloid leukaemia (AML) and MLL-rearranged leukaemia. Recently, mutations in the Casitas B lineage lymphoma (CBL) gene were reported to be involved in RAS-pathway activation in various myeloid malignancies, but their role in paediatric AML is still unknown. We performed mutation analysis of 283 newly diagnosed and 33 relapsed paediatric AML...
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