Article
Casitas B-cell lymphoma mutation in childhood T-cell acute lymphoblastic leukemia.
Leukemia research - 1 Aug 2012
Saito Yuka, Aoki Yoko, Muramatsu Hideki, Makishima Hideki, Maciejewski Jaroslaw P, Imaizumi Masue, Rikiishi Takeshi, Sasahara Yoji, Kure Shigeo, Niihori Tetsuya, Tsuchiya Shigeru, Kojima Seiji, Matsubara Yoichi
Abstract excerpt
Somatic CBL mutations have been reported in a variety of myeloid neoplasms but are rare in acute lymphoblastic leukemia (ALL). We analyzed 77 samples from hematologic malignancies, identifying a somatic mutation in CBL (p.C381R) in one patient with T-ALL that was associated with a uniparental disomy at the CBL locus and a germline heterozygous mutation in one patient with JMML. Two NOTCH1 mutations and homozygous...
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