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Article

Casitas B lymphoma mutations in childhood acute lymphoblastic leukemia.

Genes, chromosomes & cancer - 1 Mar 2012

Nicholson Lindsay, Knight Thomas, Matheson Elizabeth, Minto Lynne, Case Marian, Sanichar Maryna, Bomken Simon, Vormoor Josef, Hall Andy, Irving Julie

Abstract excerpt

Casitas B-lineage lymphoma (CBL) proteins are RING finger ubiquitin E3 ligases that attenuate the signaling of receptor tyrosine kinases and are mutated in a number of myeloid disorders. In this study, mutational screening of the linker-RING domains of CBL and CBLB was performed by denaturing high performance liquid chromatography in a cohort of diagnostic (n = 180) or relapse (n = 46) samples from children with...

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Source

Identifiers

PMID: 22072526
DOI: 10.1002/gcc.20949

Genes

CBL
CBLB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Casitas B lymphoma mutations in childhood acute lymphoblastic leukemia.PMID 22072526Read ↗

Casitas B-cell lymphoma mutation in childhood T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

CBL mutations in pediatric solid and CNS tumors are a marker of receptor tyrosine kinase activation and a potential therapeutic targetSemantic proximity Read ↗

Mutant Cbl proteins as oncogenic drivers in myeloproliferative disordersSemantic proximity Read ↗

CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1.Semantic proximity Read ↗

Molecular Diversity and Associated Phenotypic Spectrum of Germline CBL Mutations.Semantic proximity Read ↗

Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cellsSemantic proximity Read ↗

Immunological and hematological findings as major features in a patient with a new germline pathogenic CBL variant.Semantic proximity Read ↗

Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies.Semantic proximity Read ↗

E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis.Semantic proximity Read ↗

Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemiaSemantic proximity Read ↗

CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting.Semantic proximity Read ↗

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