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Article

Crystal structure of reduced and of oxidized peroxiredoxin IV enzyme reveals a stable oxidized decamer and a non-disulfide-bonded intermediate in the catalytic cycle.

The Journal of biological chemistry - 9 Dec 2011

Cao Zhenbo, Tavender Timothy J, Roszak Aleksander W, Cogdell Richard J, Bulleid Neil J

Abstract excerpt

Peroxiredoxin IV (PrxIV) is an endoplasmic reticulum-localized enzyme that metabolizes the hydrogen peroxide produced by endoplasmic reticulum oxidase 1 (Ero1). It has been shown to play a role in de novo disulfide formation, oxidizing members of the protein disulfide isomerase family of enzymes, and is a member of the typical 2-Cys peroxiredoxin family. We have determined the crystal structure of both reduced...

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Identifiers

PMID: 21994946
DOI: 10.1074/jbc.M111.298810
PMCID: PMC3234919

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