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Article

The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients.

Experimental dermatology - 1 Jan 2014

van Smeden Jeroen, Janssens Michelle, Kaye Edward C J, Caspers Peter J, Lavrijsen Adriana P, Vreeken Rob J, Bouwstra Joke A

Abstract excerpt

An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfil a predominant role in the skin barrier function. In this clinical study, the carbon chain length distribution of SC lipids (FFAs and CERs) and their importance for the lipid organization and skin barrier function were...

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Ceramides
Dermatitis, Atopic
Epidermis
Fatty Acids, Nonesterified
Filaggrin Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intermediate Filament Proteins

Lipid Metabolism

Spectroscopy, Fourier Transform Infrared

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Identifiers

PMID: 24299153
DOI: 10.1111/exd.12293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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