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Article

ErbB receptor tyrosine kinase network inhibition radiosensitizes carcinoma cells.

International journal of radiation oncology, biology, physics - 1 Jul 2006

Contessa Joseph N, Abell Angela, Valerie Kristoffer, Lin Peck-Sun, Schmidt-Ullrich Rupert K

Abstract excerpt

PURPOSE: The expression of epidermal growth factor receptor (EGFR)-CD533, a truncation mutant of the wild-type EGFR, radiosensitizes carcinoma and malignant glioma cell lines. This deletion mutant disrupts EGFR activation and downstream signaling through the formation of inhibitory dimerizations. In this study, the effects of EGFR-CD533 on other ErbB receptor tyrosine kinase (RTK) family members were quantified...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16751066
DOI: 10.1016/j.ijrobp.2006.02.025

Genes

EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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